Effect On Oral Hygiene 

Dental plaque is a sticky film of bacteria that builds up on teeth and is a major cause of tooth decay and cavities. When we eat, harmful bacteria, such as Streptococcus mutans, multiply in the mouth and create biofilms that adhere to tooth surfaces. These biofilms damage the tooth enamel and can lead to cavities over time.

DIM has proven highly effective at disrupting bacterial biofilms. Research has shown that DIM can decrease dental plaque formation by as much as 90%, greatly reducing the chances of cavities and gum disease. This natural compound breaks down the adherent layer of the biofilm, which shields the harmful bacteria. Breaking down the biofilm removes the bacteria’s protection, allowing your body to neutralize them easily and prevent dental damage.

Effects On Estrogen Levels

Research has increasingly shown that DIM plays a significant role in hormone metabolism, particularly in how the body processes estrogen. By influencing the balance of estrogen metabolites, DIM may help reduce the risks associated with hormone-driven conditions like breast cancer. Clinical studies suggest that DIM not only promotes a healthier estrogen profile but also supports the regulation of key hormone-binding proteins. These properties have gained growing interest in both cancer prevention and hormonal health

• One study published by the National Institutes of Health (NIH) found that after just 14 days of DIM supplementation, participants had significantly increased levels of 2-hydroxyestrone, a “good” protective estrogen metabolite, and decreased levels of 16 alpha-hydroxyestrone, a “bad” estrogen metabolite, linked to cancer risk.
• In a randomized, placebo-controlled trial with breast cancer patients, DIM supplementation led to beneficial shifts in estrogen metabolism and raised levels of sex hormone-binding globulin (SHBG), indicating improved hormone regulation. 
• A large observational study of over 19,000 premenopausal women demonstrated that DIM supplementation resulted in lower levels of total estrogens, reduced “bad” estrogen metabolites, and increased protective 2-OHE1 and 2-OHE2 metabolites, resulting in a more favorable estrogen metabolite ratio.

These findings highlight DIM’s potential as a natural compound for supporting hormonal balance and reducing hormone-related health risks, particularly in women.

Potential Anti-Cancer Properties: Prostate Cancer

Prostate cancer is one of the most common cancers affecting men worldwide. Researchers continue to explore alternative therapies to support traditional treatments. Clinical and preclinical studies have highlighted DIM’s potential to slow prostate cancer progression and reduce tumor growth. These findings suggest DIM may offer therapeutic value in cancer treatment.

• A phase I clinical study with prostate cancer patients who were resistant to conventional hormone therapy showed that DIM helped reduce or stabilize prostate-specific antigen (PSA) levels, which indicates slowing of cancer progression. Animal studies further supported these findings, showing prostate tumors in DIM-treated mice were reduced by up to 50%.

DIM affects multiple cancer-related pathways by reducing inflammation, blocking cell proliferation, arresting the cell cycle, promoting cancer cell death (apoptosis), and inhibiting new blood vessel formation (anti-angiogenesis), which can starve tumors.

While the results of these studies show promising outcomes, further research is needed, specifically in humans.

Foods That Promote DIM Production

DIM is naturally formed in the body when cruciferous vegetables are consumed. These vegetables are rich in glucobrassicins, which convert to DIM during digestion. Cooking these vegetables can increase the amount of DIM available by 6x.

Cruciferous vegetables that contain DIM precursors include:

• Bok choy
• Broccoli (and brocoli sprouts)
• Brussels sprouts
• Cabbage 

The Bottom Line

Avocados are a very healthy food choice rich in essential nutrients and healthy fats. They can also provide many benefits when used topically on the skin and in hair. That being said, they may not be for everyone. If you notice that your skin doesn’t seem to react well to avocado, or that you tend to feel weird or have any kind of reaction after eating avocado, stop using or consuming it. You can consult your doctor for an allergy test if you wish, though ultimately, it’s best to simply avoid foods that don’t leave you feeling your best.