When cancer appears, especially types that affect the limbs, several changes may occur. Three common changes include:

1. Bone Pain: Persistent bone pain, particularly in areas like the arms or legs, may be a sign of primary bone cancer or metastasis. The pain often increases over time and can become more severe.

2. Swelling or Lumps: The appearance of a lump or swelling in the limbs can be caused by soft tissue tumors or bone tumors. These lumps may be painful, red, or warm to the touch, and can affect the mobility of the limb.

3. Muscle Weakness or Difficulty Moving: Muscle weakness or difficulty moving the limbs can be a sign of nerve damage caused by tumor pressure or metastasis. This may lead to imbalance, difficulty walking, or even partial paralysis.

If you or a loved one experiences these symptoms, especially if they persist or worsen, it's important to consult a doctor for timely diagnosis and treatment.