One of the more recognizable signs that can occur with pancreatic cancer is jaundice, which causes the skin and whites of the eyes to become yellow.

Jaundice occurs when bilirubin, a substance produced during the normal breakdown of red blood cells, accumulates in the bloodstream.

Pancreatic tumors can sometimes block or compress the bile duct, preventing bile from flowing normally from the liver and gallbladder into the intestine.

When this happens, bilirubin can build up in the body.

Jaundice may be accompanied by dark urine and unusually pale or clay-colored stools.

Some people also develop generalized itching.

These symptoms should receive medical attention because bile duct obstruction has several possible causes, including gallstones, inflammation, liver disease, and other conditions.

Another possible digestive change involves stools that appear unusually greasy, oily, bulky, or difficult to flush.

The pancreas produces enzymes that help digest fats. If pancreatic function becomes impaired, the body may have difficulty breaking down and absorbing dietary fat.

This can result in a condition known as exocrine pancreatic insufficiency.

However, changes in stool appearance can have many explanations, and a single unusual bowel movement does not indicate pancreatic disease.

Persistent changes are more relevant.

A person who repeatedly notices greasy stools alongside unexplained weight loss or abdominal symptoms should speak with a healthcare professional.

Jaundice deserves particular attention because it can sometimes indicate obstruction of the bile ducts.

If yellowing of the eyes or skin appears suddenly, especially when accompanied by severe abdominal pain, fever, vomiting, or confusion, prompt medical assessment is important.

The same applies to significant changes in urine or stool color when they occur together with other concerning symptoms.

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Chapter 4 — Digestive Changes, Fatigue, and Blood Sugar Problems

The pancreas has an important role in digestion, but it also plays a major role in controlling blood glucose.

The pancreas produces insulin, which helps move glucose from the bloodstream into cells where it can be used for energy.