1. Changes in Skin Color:
   
   
   
   Unexplained changes in the skin color of your hands and feet, such as darkening, redness, or a bluish tint, can be a sign of cancer or other underlying health problems. Skin changes may be related to conditions like melanoma or other cancers affecting the skin or blood circulation.

2. Swelling: Unexplained swelling in the hands or feet, especially when it is persistent or worsens over time, can be a sign of an underlying issue, including cancer. This could be related to the spread of cancer or as a result of cancer treatment. Swelling may also be a sign of a blood clot or lymphedema (fluid retention), which may occur in certain cancers.

3. Pain or Numbness:
   
   
   
   

   If you experience unexplained pain, tingling, or numbness in the hands or feet, it could signal nerve damage due to cancer or its treatment. This is particularly important in cases where the cancer has spread to the nerves (e.g., in bone, lung, or prostate cancer).

4. Changes in Nails:
   
   
    

   
   Abnormalities in the nails, such as thickening, discoloration, or the appearance of white or purple streaks, can sometimes be linked to cancer. For example, melanoma, a type of skin cancer, can cause dark streaks under the nails. Additionally, cancer treatments such as chemotherapy can cause nails to become brittle, discolored, or develop vertical ridges.

It's important to remember that these signs can also be associated with other conditions. If you notice any of these symptoms or experience other unexplained changes in your hands or feet, it’s essential to seek medical advice for proper diagnosis and treatment. Early detection and intervention can significantly improve outcomes in cancer treatment.