A 42-year-old patient from Thai Nguyen, L.V.H., was admitted to the National Hospital for Tropical Diseases with severe headache, jaundice, ascites due to cirrhosis, markedly elevated liver enzymes, acute liver failure, and pneumonia. Cerebrospinal fluid testing confirmed fungal meningitis caused by Cryptococcus, accompanied by EBV and CMV co-infection and reactivation of latent hepatitis B. With a very high risk of death, physicians initiated combined treatment with antifungal medication, antiviral therapy for hepatitis B, antibiotics, and cerebrospinal fluid drainage to reduce intracranial pressure. After two months, his fever resolved, jaundice improved, liver function stabilized, and he is gradually recovering. Meningitis is an inflammation of the protective membranes of the brain and spinal cord, most commonly caused by infection from bacteria, viruses, fungi, or parasites, though trauma, chemicals, or autoimmune diseases can also be involved. The disease can occur at any age but affects infants and the elderly most severely. Early detection is crucial because meningitis progresses rapidly, and even with treatment, it may leave serious complications such as hearing loss, epilepsy, and cognitive impairment. Typical symptoms include high fever with severe headache, neck stiffness, nausea and vomiting due to increased intracranial pressure, altered consciousness, seizures, skin hemorrhages (especially in meningococcal meningitis), and sensitivity to light or sound, along with muscle or joint pain, rapid breathing, and abnormal eye movements. In infants and young children, symptoms may be subtle, including irritability, poor feeding, vomiting, bulging fontanelle, seizures, or rash. Anyone showing suspicious signs should seek immediate medical care. Prevention includes avoiding shared personal items, keeping distance from individuals with respiratory infections, covering coughs and washing hands, maintaining a healthy lifestyle, and adhering to recommended vaccinations, which remain the most effective protective measure.